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polyclonal armenian rat igg2 isotype control  (Bio X Cell)


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    Bio X Cell polyclonal armenian rat igg2 isotype control
    Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or <t>IgG</t> antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group
    Polyclonal Armenian Rat Igg2 Isotype Control, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 250 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/polyclonal+armenian+rat+igg2+isotype+control/pmc12288273-165-6-17?v=Bio+X+Cell
    Average 94 stars, based on 250 article reviews
    polyclonal armenian rat igg2 isotype control - by Bioz Stars, 2026-08
    94/100 stars

    Images

    1) Product Images from "Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer"

    Article Title: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer

    Journal: Journal of Biomedical Science

    doi: 10.1186/s12929-025-01154-6

    Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or IgG antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group
    Figure Legend Snippet: Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or IgG antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group

    Techniques Used: Over Expression, Expressing, Immunohistochemical staining, Immunohistochemistry

    CTSS inhibits the CD8 + T-cells infiltration and proliferation by downregulating IL-7. A The expression level of IL-7, IL-10, and MCP1 is plotted in the dot graph by each sample (N = 16 in each group). B The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αIL-7 or IgG antibody (N = 10 for each group). Arrowhead indicates days for antibody administration. C The representative photos of the IHC staining for CTSS, IL-7, and CD8 + T-cells for each treatment group. D Tumor infiltrative leukocytes were isolated and analyzed by FACS, the percentage of CD8 + cells in the target quadrant is plotted in the dot graph by each sample. E The percentage of Ki67 + /CD8 + cells in the target quadrant is plotted in the dot graph by each sample. F The percentage of naïve CD8 + cells, central memory CD8 + cells, effector memory CD8 + cells, and tissue-resident CD8 + cells in the target quadrant is plotted in the dot graph by each sample. G & H Mouse CD8 + T-cells were treated with CM with or without the αIL-7. The CM was obtained from in vitro NHRI-HN1 or MOC-1 that were pretreated with siScramble or si Ctss , or that with co-incubation of the mouse IL-7 recombinant protein (mIL-7). ( G) The result of the WST proliferation test for CD8 + T-cells is shown in the dot-bar graph. ( H ) The indicated scale for CFSE cell proliferation is measured and plotted in the dot-bar graph
    Figure Legend Snippet: CTSS inhibits the CD8 + T-cells infiltration and proliferation by downregulating IL-7. A The expression level of IL-7, IL-10, and MCP1 is plotted in the dot graph by each sample (N = 16 in each group). B The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αIL-7 or IgG antibody (N = 10 for each group). Arrowhead indicates days for antibody administration. C The representative photos of the IHC staining for CTSS, IL-7, and CD8 + T-cells for each treatment group. D Tumor infiltrative leukocytes were isolated and analyzed by FACS, the percentage of CD8 + cells in the target quadrant is plotted in the dot graph by each sample. E The percentage of Ki67 + /CD8 + cells in the target quadrant is plotted in the dot graph by each sample. F The percentage of naïve CD8 + cells, central memory CD8 + cells, effector memory CD8 + cells, and tissue-resident CD8 + cells in the target quadrant is plotted in the dot graph by each sample. G & H Mouse CD8 + T-cells were treated with CM with or without the αIL-7. The CM was obtained from in vitro NHRI-HN1 or MOC-1 that were pretreated with siScramble or si Ctss , or that with co-incubation of the mouse IL-7 recombinant protein (mIL-7). ( G) The result of the WST proliferation test for CD8 + T-cells is shown in the dot-bar graph. ( H ) The indicated scale for CFSE cell proliferation is measured and plotted in the dot-bar graph

    Techniques Used: Expressing, Immunohistochemistry, Isolation, In Vitro, Incubation, Recombinant



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    polyclonal armenian rat igg2 isotype control  (Bio X Cell)
    94
    Bio X Cell polyclonal armenian rat igg2 isotype control
    Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or <t>IgG</t> antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group
    Polyclonal Armenian Rat Igg2 Isotype Control, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/polyclonal+armenian+rat+igg2+isotype+control/pmc12288273-165-6-17?v=Bio+X+Cell
    Average 94 stars, based on 1 article reviews
    polyclonal armenian rat igg2 isotype control - by Bioz Stars, 2026-08
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or IgG antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group

    Journal: Journal of Biomedical Science

    Article Title: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer

    doi: 10.1186/s12929-025-01154-6

    Figure Lengend Snippet: Overexpression of CTSS in HNC tissue is inversely correlated with CD8 + T-cell infiltration. A & B The dot graphs show the mRNA expression levels of CTSS in the head and neck cancer (HNC) datasets from ( A ) TCGA and ( B ) GEO ( GSE6791 ). C The representative photos of the CTSS immunohistochemical (IHC) staining on the HNC tissue array. The dot graphs summarize the quantitative score of each sample by stratification. D & E The representative photos of IHC staining for ( D ) CTSS expression and ( E ) CD8 + T-cell infiltration of the in-house oral cancer (OC) samples were shown (N = 70). The score of each sample is plotted by different parameters on the right panels. F & G The correlation between the IHC staining score of CTSS and CD8 in the in-house OC samples was studied. The results are shown by dot graph plots for ( F ) the entire cohort (N = 70) and ( G ) samples with T1 and T2 Stage (N = 38). H The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αCD8 or IgG antibody (N = 6 for each group). Arrowhead indicates days for antibody administration. I The representative photos of the IHC staining for CTSS and CD8 + T cells for each treatment group

    Article Snippet: Antibodies were listed in the following: Polyclonal Armenian rat IgG2 isotype control (10 μg/mice) ( cat# BE0086; BioXcell, Lebanon, NH, USA), Anti-mouse/human IL-7 antibody (αIL-7) (10 μg/mice) ( cat# BE0048; BioXcell), Polyclonal Armenian hamster IgG (100 μg/mice) ( cat# BE0091; BioXcell), αPD-1 (100 μg/mice) ( cat# BE0033-2; BioXcell), Rat IgG1 isotype control, anti-horseradish peroxidase (200 μg/mice) ( cat# BP0088; BioXcell), Anti-mouse CD8b antibody (Lyt3.2) (αCD8) (200 μg/mice) ( cat# BE0223; BioXcell).

    Techniques: Over Expression, Expressing, Immunohistochemical staining, Immunohistochemistry

    CTSS inhibits the CD8 + T-cells infiltration and proliferation by downregulating IL-7. A The expression level of IL-7, IL-10, and MCP1 is plotted in the dot graph by each sample (N = 16 in each group). B The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αIL-7 or IgG antibody (N = 10 for each group). Arrowhead indicates days for antibody administration. C The representative photos of the IHC staining for CTSS, IL-7, and CD8 + T-cells for each treatment group. D Tumor infiltrative leukocytes were isolated and analyzed by FACS, the percentage of CD8 + cells in the target quadrant is plotted in the dot graph by each sample. E The percentage of Ki67 + /CD8 + cells in the target quadrant is plotted in the dot graph by each sample. F The percentage of naïve CD8 + cells, central memory CD8 + cells, effector memory CD8 + cells, and tissue-resident CD8 + cells in the target quadrant is plotted in the dot graph by each sample. G & H Mouse CD8 + T-cells were treated with CM with or without the αIL-7. The CM was obtained from in vitro NHRI-HN1 or MOC-1 that were pretreated with siScramble or si Ctss , or that with co-incubation of the mouse IL-7 recombinant protein (mIL-7). ( G) The result of the WST proliferation test for CD8 + T-cells is shown in the dot-bar graph. ( H ) The indicated scale for CFSE cell proliferation is measured and plotted in the dot-bar graph

    Journal: Journal of Biomedical Science

    Article Title: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer

    doi: 10.1186/s12929-025-01154-6

    Figure Lengend Snippet: CTSS inhibits the CD8 + T-cells infiltration and proliferation by downregulating IL-7. A The expression level of IL-7, IL-10, and MCP1 is plotted in the dot graph by each sample (N = 16 in each group). B The tumor volume of the subcutaneously-inoculated NHRI-HN1 cell is plotted. Mice were implanted with tumors carrying either sh Ctss or shControl, and were grouped by treatment with αIL-7 or IgG antibody (N = 10 for each group). Arrowhead indicates days for antibody administration. C The representative photos of the IHC staining for CTSS, IL-7, and CD8 + T-cells for each treatment group. D Tumor infiltrative leukocytes were isolated and analyzed by FACS, the percentage of CD8 + cells in the target quadrant is plotted in the dot graph by each sample. E The percentage of Ki67 + /CD8 + cells in the target quadrant is plotted in the dot graph by each sample. F The percentage of naïve CD8 + cells, central memory CD8 + cells, effector memory CD8 + cells, and tissue-resident CD8 + cells in the target quadrant is plotted in the dot graph by each sample. G & H Mouse CD8 + T-cells were treated with CM with or without the αIL-7. The CM was obtained from in vitro NHRI-HN1 or MOC-1 that were pretreated with siScramble or si Ctss , or that with co-incubation of the mouse IL-7 recombinant protein (mIL-7). ( G) The result of the WST proliferation test for CD8 + T-cells is shown in the dot-bar graph. ( H ) The indicated scale for CFSE cell proliferation is measured and plotted in the dot-bar graph

    Article Snippet: Antibodies were listed in the following: Polyclonal Armenian rat IgG2 isotype control (10 μg/mice) ( cat# BE0086; BioXcell, Lebanon, NH, USA), Anti-mouse/human IL-7 antibody (αIL-7) (10 μg/mice) ( cat# BE0048; BioXcell), Polyclonal Armenian hamster IgG (100 μg/mice) ( cat# BE0091; BioXcell), αPD-1 (100 μg/mice) ( cat# BE0033-2; BioXcell), Rat IgG1 isotype control, anti-horseradish peroxidase (200 μg/mice) ( cat# BP0088; BioXcell), Anti-mouse CD8b antibody (Lyt3.2) (αCD8) (200 μg/mice) ( cat# BE0223; BioXcell).

    Techniques: Expressing, Immunohistochemistry, Isolation, In Vitro, Incubation, Recombinant